The gas mileage has been somewhat better than other vehicles I have owned in the past. I have had a couple other vans as well and this one has a bit more space for the family, plus I really like the sliding door on the driver's side makes getting everyone in without fights easier.
There are a number of problems with this type of vehicle that has been posted by numerous owners. The gas line wasn't thought of carefully enough in my opinion and leads to many owners leaking gas due to this problem.
The 2005 Chevrolet Uplander has an average owner rating of 3.96 out of 5 which ranks it #8 of 11 other Minivans.
From the Vehicle History blog
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Overall
Front
Rollover
Side
Moderate Overlap Front
Side
Roof Strength
Driver-side Overlap Front