Love my ml350 after moving from a suburban.
Bought the car used with 28k miles. Have never had any problems with it thus far. Moved from a suburban to the ml-350; love the size, comfort and features. It handles well and is responsive. The seats are comfortable and there is plenty of legroom in the back. The rear area has much more storage space than it appears from the outside and the seats fold down for even more space. The sound system is excellent and I love the Bluetooth/hand-free phone. Gas mileage is not great, but moving from a suburban it is still better than 8 miles/gallon. My only complaint is that it does not always handle great in the rain; wheels feel to sometimes slip, but this may be a tire issue.