Reliable: For generations
2005 Toyota Sienna CE
This van handles well, but really gets blown around on the highway. It has been passed through four separate drivers and has seen two minor accidents, one of which I fixed myself since everything is still relatively user serviceable in this model of car.
The brakes and heat shields are liable to rust like any other car but each of those are relatively easy to replace too. I believe the car has over 130,000 miles with no serious mechanical work needed.
The seats are comfortable and there is plenty of room in the back to carry large items, and all of the seats can be folded into the floor or removed for more space. I completed two construction projects using this van like a truck due to its large capacity.