Why is my 2013 Ford f250 radio not working?

You're going to need to be more specific about what's not working with Your radio on Your 2013 Ford F-250. Are some of the functions not performing properly Is the Audio cutting out while You're driving Are the volume controls non-responsive Or are we just talking garden variety not turning on For the latter case, the number one reason here is going to be a blown fuse; this is pretty easy to check, by popping the panel on the interior fuse boxAnd checking there. More serious causes here could be the wiring to the radio. I'm assuming the radio was working before and isn't now: If You've just purchased this as a used vehicle, there's a non-zero chance the wiring hasn't been hooked up at all.