How do I replace the 2010 Ford Ranger rear wheel bearing?

The short answer for how You should replace the rear wheel bearing on Your 2010 Ford Ranger is that You shouldn't: You should take it into a mechanic, and pay the cost, somewhere between $250 to $500 in labor and around $200 for the parts. This sounds like a lot, but unless You've got the press to use on the wheel bearing to mate it with the steering knuckle or spindle, You're going to be dead in the water. The procedure, in theory, isn't that hard. You'll need to take off Your tire after jacking up the Ranger, remove the hub assembly and bearings from the axle, and then reverse the procedure, using an adequate amount of grease. However, this really is a procedure You should trust to a mechanic, given the consequences of making an error during the process.