What are some of the 2000 mercedes e320 transmission problems?

The 2000 Mercedes Benz E320 is known for its luxurious ride, and it's also a relatively reliable vehicle. As such, there aren't many transmission issues that are unique to the E320, but that doesn't mean You're exempt from regular maintenance; failure to do so could put You in the same boat as the rest of us. One of the most common issues drivers report is transmission damage caused from overheating. Overheating can happen for a number of reasons, but the main one is trying to haul too much weight or running on low or broken down trans fluid. You should change Your fluid every 30,000 miles, and check levels every 5,000 miles or so. This can help prevent transmission issues by keeping the moving parts properly lubricated.