What is the toyota sienna tune up cost?

The term "tune up" is very general, and doesn't include the specific maintenance desired. Therefore, it's impossible for me to understand what You mean by a tune up -- You might be looking at around $40 for a budget oil change, or upwards of $1000 for all fluid changes, filter replacements (including cabin, air, and oil), spark plug replacements, a battery replacement, a brake replacement, and an all around lubrication. Therefore, the best answer I can give You is that varies. Sometimes wildly. The best way to mitigate cost is to stay on top of Your maintenance schedule and get things done as they come up -- You should be changing oil about every 5,000 to 6,000 miles, transmission fluid every 25,000 to 40,000 miles, air filters (intake and cabin, if equipped) every 15,000 miles, and brakes and spark plugs as needed.